abstract：:The formation of a heterotetrameric complex between annexin 2 (anx 2) and S100A10 plays an important role in regulating the cellular distribution and biochemical properties of anx 2. A major distinction between the anx 2-S100A10 complex and other annexin-S100 complexes is that S100A10 binding to anx 2 occurs independe...

journal_title：Cell calcium

authors： Borthwick LA,Neal A,Hobson L,Gerke V,Robson L,Muimo R

更新日期：2008-08-01 00:00:00

abstract：:Increases in global Ca(2+) in the endothelium are a crucial step in releasing relaxing factors to modulate arterial tone. In the present study we investigated spontaneous Ca(2+) events in endothelial cells, and the contribution of smooth muscle cells to these Ca(2+) events, in pressurized rat mesenteric resistance art...

journal_title：Cell calcium

authors： Kansui Y,Garland CJ,Dora KA

更新日期：2008-08-01 00:00:00

abstract：:Signal transduction by auditory and vestibular hair cells involves an impressive ensemble of finely tuned control mechanisms, strictly dependent on the local intracellular Ca(2+) concentration ([Ca(2+)](i)). The study of Ca(2+) dynamics in hair cells typically combines Ca(2+)-sensitive fluorescent indicators (dyes), p...

journal_title：Cell calcium

authors： Bortolozzi M,Lelli A,Mammano F

更新日期：2008-08-01 00:00:00

abstract：:NADH:ubiquinone oxidoreductase or complex I is a large multisubunit assembly of the mitochondrial inner membrane that channels high-energy electrons from metabolic NADH into the electron transport chain (ETC). Its dysfunction is associated with a range of progressive neurological disorders, often characterized by a ve...

journal_title：Cell calcium

authors： Willems PH,Valsecchi F,Distelmaier F,Verkaart S,Visch HJ,Smeitink JA,Koopman WJ

更新日期：2008-07-01 00:00:00

abstract：:Pancreatitis is an increasingly common disease that carries a significant mortality and which lacks specific therapy. Pathological calcium signalling is an important contributor to the initiating cell injury, caused by or acting through mitochondrial inhibition. A principal effect of disordered cell signalling and imp...

journal_title：Cell calcium

authors： Mukherjee R,Criddle DN,Gukovskaya A,Pandol S,Petersen OH,Sutton R

更新日期：2008-07-01 00:00:00

abstract：:Receptors for extracellular nucleotides (the P2X-calcium channels and the phospholipase C-coupled P2Y receptors) play key roles in pain signaling, but little is known on their function in trigeminal ganglia, whose hyperactivation leads to the development of migraine pain. Here we characterize calcium signaling via P2X...

journal_title：Cell calcium

authors： Ceruti S,Fumagalli M,Villa G,Verderio C,Abbracchio MP

更新日期：2008-06-01 00:00:00

abstract：:NAADP (nicotinic acid adenine dinucleotide phosphate) is a recently discovered second messenger, and as such, we have much yet to learn about its functions in health and disease. A bottleneck in this basic research is due to NAADP, like all second messengers, being charged to prevent it from leaking out of cells. This...

journal_title：Cell calcium

authors： Parkesh R,Lewis AM,Aley PK,Arredouani A,Rossi S,Tavares R,Vasudevan SR,Rosen D,Galione A,Dowden J,Churchill GC

更新日期：2008-06-01 00:00:00

abstract：:Transient spontaneous increases in the intracellular Ca2+ concentration have been frequently observed in astrocytes in cell culture and in acutely isolated slices from several brain regions. Recent in vivo experiments, however, reported only a low frequency of spontaneous Ca2+ events in astrocytes. Since the ex vivo e...

journal_title：Cell calcium

authors： Schipke CG,Heidemann A,Skupin A,Peters O,Falcke M,Kettenmann H

更新日期：2008-03-01 00:00:00

abstract：:Dynamic nuclear Ca(2+) signals play pivotal roles in diverse cellular functions including gene transcription, cell growth, differentiation, and apoptosis. Here we report a novel nuclear Ca(2+) regulatory mechanism mediated by inositol 1,4,5-trisphosphate receptors (IP(3)Rs) around the nucleus in developing cardiac myo...

journal_title：Cell calcium

authors： Luo D,Yang D,Lan X,Li K,Li X,Chen J,Zhang Y,Xiao RP,Han Q,Cheng H

更新日期：2008-02-01 00:00:00

abstract：:The peptide of HIV-1 envelope gp41 (a.a 628-683), referred to herein as P5, contains P1, a conserved galactose-specific lectin domain for binding the mucosal HIV-1-receptor, galactosyl ceramide (GalCer), as shown earlier, and a potential calcium-binding site (a.a 628-648). P1 contains contiguous epitopes recognized by...

journal_title：Cell calcium

authors： Yu H,Alfsen A,Tudor D,Bomsel M

更新日期：2008-01-01 00:00:00

abstract：:We have previously demonstrated a role for the reorganization of the actin cytoskeleton in store-operated calcium entry (SOCE) in human platelets and interpreted this as evidence for a de novo conformational coupling step in SOCE activation involving the type II IP(3) receptor and the platelet hTRPC1-containing store-...

journal_title：Cell calcium

authors： Harper AG,Sage SO

更新日期：2007-12-01 00:00:00

abstract：:Ca2+ is a fundamental intracellular signal that mediates a variety of disparate physiological functions often in the same cell. Ca2+ signals span a wide range of spatial and temporal scales, which endow them with the specificity required to induce defined cellular functions. Furthermore, Ca2+ signaling is highly plast...

journal_title：Cell calcium

authors： Ullah G,Jung P,Machaca K

更新日期：2007-12-01 00:00:00

abstract：:Central to controlling intracellular calcium concentration ([Ca(2+)](i)) are a number of Ca(2+) transporters and channels with the L-type Ca(2+) channel, Na(+)-Ca(2+) exchanger and sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) being of particular note in the heart. This review concentrates on the regulation of [Ca(2+)]...

journal_title：Cell calcium

authors： Dibb KM,Graham HK,Venetucci LA,Eisner DA,Trafford AW

更新日期：2007-10-01 00:00:00

abstract：:Specific Ca(2+) homeostatic system appeared very early in the history of the cell, as a survival system preventing Ca(2+)-mediated cell damage. This homeostatic system produced a steep ( approximately 20,000 times) concentration gradient between extracellular and intracellular compartments, which has both survival imp...

journal_title：Cell calcium

authors： Case RM,Eisner D,Gurney A,Jones O,Muallem S,Verkhratsky A

更新日期：2007-10-01 00:00:00

abstract：:In smooth muscle, Ca(2+) regulates cell division, growth and cell death as well as providing the main trigger for contraction. Ion channels provide the major access route to elevate the cytoplasmic Ca(2+) concentration ([Ca(2+)](c)) in smooth muscle by permitting Ca(2+) entry across the plasma membrane and release of ...

journal_title：Cell calcium

authors： Chalmers S,Olson ML,MacMillan D,Rainbow RD,McCarron JG

更新日期：2007-10-01 00:00:00

abstract：:Voltage activated L-type Ca(2+) channels are the principal Ca(2+) channels in intestinal smooth muscle cells. They comprise the ion conducting Ca(V)1 pore and the ancillary subunits alpha(2)delta and beta. Of the four Ca(V)beta subunits Ca(V)beta(3) is assumed to be the relevant Ca(V)beta protein in smooth muscle. In ...

journal_title：Cell calcium

authors： Held B,Tsvilovskyy V,Meissner M,Kaestner L,Ludwig A,Mossmang S,Lipp P,Freichel M,Flockerzi V

更新日期：2007-10-01 00:00:00

abstract：:In non-excitable cells, the inositol 1,4,5-trisphosphate receptor (IP3R) is an intracellular Ca2+ channel which plays a major role in Ca2+ signalling. Three isoforms of IP3R have been identified (IP3R-1, IP3R-2 and IP3R-3) and most cell types express different proportions of each isoform. The differences between the p...

journal_title：Cell calcium

authors： Caron AZ,Chaloux B,Arguin G,Guillemette G

更新日期：2007-09-01 00:00:00

abstract：:Ca(2+) signals are universal among cells in regulating a spectrum of cellular responses. Phospholipase C-coupled receptors activate two components of Ca(2+) signals--rapid Ca(2+) release from ER stores, followed by slower Ca(2+) entry from outside the cell. The coupling process between ER and PM to mediate this "store...

journal_title：Cell calcium

authors： Hewavitharana T,Deng X,Soboloff J,Gill DL

更新日期：2007-08-01 00:00:00

abstract：:Although store-operated calcium entry (SOCE) was identified more that two decades ago, understanding the molecular mechanisms that regulate and mediate this process continue to pose a major challenge to investigators in this field. Thus, there has been major focus on determining which of the models proposed for this m...

journal_title：Cell calcium

authors： Ambudkar IS,Ong HL,Liu X,Bandyopadhyay BC,Cheng KT

更新日期：2007-08-01 00:00:00

abstract：:In the brain, classical (canonical) transient receptor potential (TRPC) channels are thought to be involved in different aspects of neuronal development. We investigated the developmental expression profile of TRPC channels in rat cerebellum during the first 6 weeks after birth. TRPC3 expression is significantly up-re...

journal_title：Cell calcium

authors： Huang WC,Young JS,Glitsch MD

更新日期：2007-07-01 00:00:00

abstract：:In HEK293 cells, transfected with the Ca2+ channel protein TRPV6, Ca2+ influx is increased and TRPV6 is tyrosine phosphorylated following addition of the tyrosine phosphatase inhibitor N,N-dimethyl-hydroxamido hydroxovanadate to cells. This effect of DMHV is enhanced by co-transfection of cells with the tyrosine kinas...

journal_title：Cell calcium

authors： Sternfeld L,Anderie I,Schmid A,Al-Shaldi H,Krause E,Magg T,Schreiner D,Hofer HW,Schulz I

更新日期：2007-07-01 00:00:00

abstract：:NAADP has been shown to act as a second messenger in a wide range of systems from plants to mammalian cells. Although it had always been considered as a canonical second messenger, recent work has shown that it is also active when applied extracellularly. It has also been suggested that NAADP might have a direct actio...

journal_title：Cell calcium

authors： Billington RA,Genazzani AA

更新日期：2007-06-01 00:00:00

abstract：:Within the CNS, distinct neurons may rely on different processes to modulate cytosolic Ca2+ depending on the network developmental phase. In particular, in the immature spinal cord, synchronous electrical discharges are coupled with biochemical signals triggered by intracellular Ca2+ waves. Nevertheless, the presence ...

journal_title：Cell calcium

authors： Fabbro A,Pastore B,Nistri A,Ballerini L

更新日期：2007-04-01 00:00:00

abstract：:Intracellular calcium signals activated by growth factors in endothelial cells during angiogenesis regulate cytosolic and nuclear events involved in survival, proliferation and motility. Among the intracellular messengers released after proangiogenic stimulation (bFGF, VEGF), arachidonic acid (AA), nitric oxide (NO) a...

journal_title：Cell calcium

authors： Tomatis C,Fiorio Pla A,Munaron L

更新日期：2007-03-01 00:00:00

abstract：:We have used single cell fluorescence imaging techniques to examine how functional properties of the caffeine-sensitive Ca(2+) store change during differentiation of a sub-population of caffeine-sensitive SH-SY5Y cells. Application of caffeine (30 mM) 1-10.5 min after a 'priming' depolarisation pulse of 55 mM K(+) rev...

journal_title：Cell calcium

authors： Riddoch FC,Brown AM,Rowbotham SE,Redfern CP,Cheek TR

更新日期：2007-03-01 00:00:00

abstract：:Here, we report a novel role for the cysteine protease calpain in store-operated calcium entry. Several structurally and mechanistically unrelated inhibitors of calpain inhibited Ca2+ entry activated in human platelets by thapsigargin-evoked Ca2+ store depletion or the physiological agonist thrombin, whereas inhibitor...

journal_title：Cell calcium

authors： Harper AG,Sage SO

更新日期：2007-02-01 00:00:00

abstract：:TRP family of proteins are components of unique cation channels that are activated in response to diverse stimuli ranging from growth factor and neurotransmitter stimulation of plasma membrane receptors to a variety of chemical and sensory signals. This review will focus on members of the TRPC sub-family (TRPC1-TRPC7)...

journal_title：Cell calcium

authors： Ambudkar IS,Bandyopadhyay BC,Liu X,Lockwich TP,Paria B,Ong HL

更新日期：2006-11-01 00:00:00

abstract：:Katz and co-workers showed that Ca(2+) triggers exocytosis. The existence of sub-micrometer domains of greater than 100 microM [Ca(2+)](i) was postulated on theoretical grounds. Using a modified, low-affinity aequorin, Llinas et al. were the first to demonstrate the existence of Ca(2+) 'microdomains' in squid presynap...

journal_title：Cell calcium

authors： Oheim M,Kirchhoff F,Stühmer W

更新日期：2006-11-01 00:00:00

abstract：:Neurons generate particular calcium microdomains in response to different stimuli. Calcium microdomains have a central role in a variety of neuronal functions. In particular, calcium microdomains participate in long-lasting synaptic plasticity--a neuronal response presumably correlated with cognitive brain functions t...

journal_title：Cell calcium

authors： Carrasco MA,Hidalgo C

更新日期：2006-11-01 00:00:00

abstract：:Specific sequences (cis-acting elements) in the 3'-untranslated region (UTR) of RNA, together with stabilizing and destabilizing proteins (trans-acting factors), determine the mRNA stability, and consequently, the level of expression of several proteins. Such interactions were discovered initially for short-lived mRNA...

journal_title：Cell calcium

authors： Misquitta CM,Chen T,Grover AK

更新日期：2006-10-01 00:00:00

abstract：:Low-voltage-activated T-type calcium channels are expressed in various tissues, especially in the brain, where they promote neuronal firing and are involved in slow wave sleep and absence epilepsy. While the transduction pathways by which hormones and neurotransmitters modulate high-voltage-activated calcium channels ...

journal_title：Cell calcium

authors： Chemin J,Traboulsie A,Lory P

更新日期：2006-08-01 00:00:00

abstract：:Burst firing of the thalamic neurons is driven by the low threshold Ca2+ spike generated by Ca2+ influx through T-type Ca2+ channels when these channels are activated by membrane hyperpolarization due to inhibitory inputs. The major inhibitory inputs to the thalamocortical (TC) neurons are from the GABAergic neurons i...

journal_title：Cell calcium

authors： Shin HS

更新日期：2006-08-01 00:00:00

abstract：:Evidence is accumulating on a key role of T-type channels in neurotransmitter release. Recent works have brought undisputable proofs that T-type channels are capable of controlling hormone and neurotransmitters release in association with exocytosis of large dense-core and synaptic vesicles. T-type channel-secretion c...

journal_title：Cell calcium

authors： Carbone E,Giancippoli A,Marcantoni A,Guido D,Carabelli V

更新日期：2006-08-01 00:00:00

abstract：:Ca(2+) signals control DNA synthesis and repair, gene transcription, and other cell functions that occur within the nucleus. The nuclear envelope can store Ca(2+) and release it into the nucleus via either the inositol 1,4,5-trisphosphate receptor (InsP3R) or the ryanodine receptor (RyR). Furthermore, many cell types ...

journal_title：Cell calcium

authors： Marius P,Guerra MT,Nathanson MH,Ehrlich BE,Leite MF

更新日期：2006-01-01 00:00:00

abstract：:We studied the contribution of store-operated or capacitative Ca2+-entry (SOCE or CCE, respectively) through store-operated Ca2+ channels (SOCCs) and the contribution of Ca2+-entry through receptor-operated, non-selective cation channels (ROCCs or NSCCs, respectively), on the M3-receptor-mediated (270 nM Ach) contract...

journal_title：Cell calcium

authors： Weirich J,Dumont L,Fleckenstein-Grün G

更新日期：2005-11-01 00:00:00

abstract：:A rapid increase in intracellular calcium directly triggers regulated exocytosis. In addition, changes in intracellular calcium concentration can adjust the extent of exocytosis (quantal content) or the magnitude of individual release events (quantal size) in both the short- and long-term. It is generally agreed that ...

journal_title：Cell calcium

authors： Barclay JW,Morgan A,Burgoyne RD

更新日期：2005-09-01 00:00:00

abstract：:Ca2+ signalling governs stimulated exocytosis and exocytosis-coupled endocytosis also in Paramecium cells. Upon stimulation, the < or =10(3) dense-core exocytotic organelles (trichocysts) can be synchronously (80 ms) released, followed by endocytotic membrane resealing (350 ms) and retrieval. Paramecium is the most sy...

journal_title：Cell calcium

authors： Plattner H,Kissmehl R

更新日期：2005-09-01 00:00:00

abstract：:Factors contributing to "local control" of Ca2+ release in cardiac myocytes are incompletely understood. We induced local release of Ca2+ by regional exposure of mouse atrial and ventricular myocytes to 10mM caffeine for 500 ms using a rapid solution switcher. Propagation of Ca2+ release was imaged by means of a Nipko...

journal_title：Cell calcium

authors： Seguchi H,Ritter M,Shizukuishi M,Ishida H,Chokoh G,Nakazawa H,Spitzer KW,Barry WH

更新日期：2005-07-01 00:00:00

abstract：:Polycystin-2, a member of the TRP family of calcium channels, is encoded by the human PKD2 gene. Mutations in that gene can lead to swelling of nephrons into the fluid-filled cysts of polycystic kidney disease. In addition to expression in tubular epithelial cells, human polycystin-2 is found in muscle and neuronal ce...

journal_title：Cell calcium

authors： Koulen P,Duncan RS,Liu J,Cohen NE,Yannazzo JA,McClung N,Lockhart CL,Branden M,Buechner M

更新日期：2005-06-01 00:00:00

abstract：:A characteristic feature of developing neural networks is spontaneous periodic activity. In the developing retina, retinal ganglion cells fire bursts of action potentials that drive large increases in intracellular calcium concentration with a periodicity of minutes. These periodic bursts of action potentials propagat...

journal_title：Cell calcium

authors： Firth SI,Wang CT,Feller MB

更新日期：2005-05-01 00:00:00